Bevacizumab-Induced Pneumonitis in a Patient With Metastatic Colon Cancer: A Case Report

© The Author(s) 2020. Bevacizumab is a vascular endothelial growth factor–directed humanized monoclonal antibody used to treat many types of cancer and some eye diseases. Due to inhibition of angiogenesis, many adverse reactions such as bowel necrosis, nasal septal perforation, and renal thrombotic microangiopathy have been described. However, its association with interstitial pneumonitis is scarcely reported in the literature. We report a case of a 79-year-old woman with metastatic colon cancer who presented with cough and dyspnea on exertion the day after initiation of bevacizumab. She was found to have bilateral airspace opacities on imaging. Infectious and cardiogenic etiologies of dyspnea were ruled out. Due to the temporal relationship with the initiation of chemotherapy, she was suspected to have developed bevacizumab-induced interstitial pneumonitis. She improved rapidly with high-dose steroids. Follow-up imaging showed resolution of infiltrates. This is the first reported case in the literature that directly links bevacizumab to interstitial pneumonitis

Single stage bilateral total hip replacement: Is it an option or a risk?

Abstract OBJECTIVE: To evaluate safety and feasibility of two-stage total hip arthroplasty and to compare it with single-stage procedure. METHODS: The retrospective study was conducted at The Aga Khan University Hospital and comprised all cases of total hip replacements between January 2001 and December 2014 that were retrieved from the database using International Classification of Diseases (9th Revision) coding. A standardised questionnaire was completed, including patient demographics, primary diagnosis, peri and postoperative morbidity and mortality. Differences among patients\\u27 data were analysed using chi square test for dichotomous variables and student t-test for continuous variables. RESULTS: Of the 48 cases, 34(71%) had single-stage bilateral total hip replacement and 14(29%) had two-stage procedure. The mean hospital stay in the single-stage group was 8.1±3.2 days compared to 19.6±5 days in the other group. The two-stage group required a significantly greater need for transfusion compared to the single-stage group (P\u3c0.05). There was no statistically significant increase in peri or postoperative complication (p\u3e 0.05). CONCLUSIONS: Simultaneous bilateral total hip arthroplasty was found to be a safe and viable option with a decreased transfusion requirement and shorter hospital stay along with no significant increase in morbidity or mortality

Experimental study of masonry wall exposed to blast loading

The challenge of protecting the nation against the attack of terrorism has raised the importance to explore the understanding of building materials against the explosion. Unlike most of the building materials, brick masonry materials offer relatively small resistance against blast loading. In this research, a brick masonry wall was exposed to varying blast load at different scaled distances. Six tests with different amounts of explosives at various distances were carried out. Pressure time history, acceleration time history and strain at specific location were measured. The parameters measured from experimental pressure time history and acceleration time history is compared with those determined by ConWep to establish the correlations between experimental determined records and ConWep values. The experimental results were also compared with some researchers. These correlations may assist in understanding the behaviour of masonry structures subjected to explosive loading

Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt

Mesenchymal stem cells (MSCs) are multipotent precursor cells originating from several adult connective tissues. MSCs possess the ability to self-renew and differentiate into several lineages, and are recognized by the expression of unique cell surface markers. Several lines of evidence suggest that various signal transduction pathways and their interplay regulate MSC differentiation. To that end, a critical player in regulating MSC differentiation is a group of proteins encoded by the Wnt gene family, which was previously known for influencing various stages of embryonic development and cell fate determination. As MSCs have gained significant clinical attention for their potential applications in regenerative medicine, it is imperative to unravel the mechanisms by which molecular regulators control differentiation of MSCs for designing cell-based therapeutics. It is rather coincidental that the functional outcome(s) of Wnt-induced signals share similarities with cellular redox-mediated networks from the standpoint of MSC biology. Furthermore, there is evidence for a crosstalk between Wnt and redox signalling, which begs the question whether Wnt-mediated differentiation signals involve the intermediary role of reactive oxygen species. In this review, we summarize the impact of Wnt signalling on multi-lineage differentiation of MSCs, and attempt to unravel the intricate interplay between Wnt and redox signals

Radio Resource Management in NB-IoT Systems:Empowered by Interference Prediction and Flexible Duplexing

NB-IoT is a promising cellular technology for enabling low cost, low power, long-range connectivity to IoT devices. With the bandwidth requirement of 180 kHz, it provides the flexibility to deploy within the existing LTE band. However, this raises serious concerns about the performance of the technology due to severe interference from multi-tier 5G HetNets. Furthermore, as NB-IoT is based on HD-FDD, the symmetric allocation of spectrum band between the downlink and uplink results in underutilization of resources, particularly in the case of asymmetric traffic distribution. Therefore, an innovative RRM strategy needs to be devised to improve spectrum efficiency and device connectivity. This article presents the detailed design challenges that need to be addressed for the RRM of NB-IoT and proposes a novel framework to devise an efficient resource allocation scheme by exploiting cooperative interference prediction and flexible duplexing techniques

Sustainable Smart Transportation System: Through the Lens of a Smart City in an Emerging Country

Environmental and social sustainability continue to challenge urban development agendas, especially in emerging markets. Past literature on the topic of smart, sustainable cities has focused relatively less on developing countries – however, during the transient phase, such economies undergo several stages of development which this paper endeavors to investigate. The goal is to define key dimensions essential for evolving existing urban sites into a sustainable ecosystem. In this context, this study puts forward a framework consisting of five pillars: Scalability, Connection, Availability, Productivity, and Environment (SCAPE) to guide the implementation of sustainable cities in developing and tropical countries

Molten Salt/Metal Foam/Graphene Nanoparticle Phase Change Composites for Thermal Energy Storage

The binary and ternary mixtures of nitrates are desirable phase change materials (PCMs) as latent heat thermal energy storage media for solar energy applications. In this study, graphene oxide was synthesized with graphite powder first and then it was doped into HITEC salt or solar salt solvent with sonication using two-step methods. Finally, metal foams including nickel and copper ones were impregnated with the salt seeded with graphene (nanocomposite). The morphologies of the synthesized composite PCMs were analyzed extensively, while the thermophysical properties of the composite PCMs were both theoretically predicted and experimentally investigated. The results indicated that metal foam was compatible with nanocomposite and the thermal stabilities of the composite PCMs were good regarding the thermal cycle characteristics. The effective thermal conductivities of the salt/graphene/metal foam composites were distinctly enhanced, while the latent heats of the present composite PCMs were smaller than that of pure salt to some extent. Furthermore, the phase change temperatures shifted slightly in the presence of porous metal foam and graphene, while the addition of graphene could compensate for the reduction of specific heats of the composite PCMs caused by metal foam. Finally, it was found that the thermal effusivities of the salt/graphene/metal foam composites were larger than those of pure salt, indicating the increments of 110%∼270% in solid state and 150%∼360% in liquid state, respectively. Fundamental information on the nanocomposites with porous media could broaden their application in thermal energy storage systems

AI-driven optimization of ethanol-powered internal combustion engines in alignment with multiple SDGs: A sustainable energy transition

With the escalating requirement for global sustainable energy solutions and the complexities linked with the complete transition to new technologies, internal combustion engines (ICEs) powered with biofuels like ethanol are gaining significance over time. However, problems linked to the performance and emissions of such ICEs necessitate accurate prediction and optimization. The study employed the integration of artificial neural networks (ANN) and multi-level historical design of response surface methodology (RSM) to address these challenges in alignment with the Sustainable Development Goals (SDGs). A single-cylinder spark ignition (SI) engine powered with ethanol-gasoline blends at different loads and speeds was used to gather data. Among six initially trained ANN models, the most efficient model with a regression coefficient (R2) of 0.9952 (training), 0.98579 (validation), 0.98847 (testing), and 0.99307 (overall) was employed to predict outputs such as brake power, brake specific fuel consumption (BSFC), brake thermal energy (BTE), concentration of carbon dioxide (CO2), carbon monoxide (CO), hydrocarbons (HC), and oxides of nitrogen NOx. Predicted outputs were optimized by incorporating RSM. On implementing optimized conditions, it was observed that BP and BTE increased by 19.9%, and 29.8%, respectively. Additionally, CO, and HC emissions experienced substantial reductions of 28.1%, and 40.6%, respectively. This research can help engine producers and researchers make refined decisions and achieve improved performance and emissions. The study directly supports SDG 7, SDG 9, SDG 12, SDG 13, and SGD 17, which call for achieving affordable, clean energy, sustainable industrialization, responsible consumption, and production, taking action on climate change, and partnership to advance the SDGs as a whole respectively

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation

Background: Chemotherapy-induced reduction in tumor load is a function of apoptotic cell death, orchestrated by intracellular caspases. However, the effectiveness of these therapies is compromised by mutations affecting specific genes, controlling and/or regulating apoptotic signaling. Therefore, it is desirable to identify novel pathways of cell death, which could function in tandem with or in the absence of efficient apoptotic machinery. In this regard, recent evidence supports the existence of a novel cell death pathway termed autophagy, which is activated upon growth factor deprivation or exposure to genotoxic compounds. The functional relevance of this pathway in terms of its ability to serve as a stress response or a truly death effector mechanism is still in question; however, reports indicate that autophagy is a specialized form of cell death under certain conditions. Methodology/Principal Findings: We report here the simultaneous induction of non-canonical autophagy and apoptosis in human cancer cells upon exposure to a small molecule compound that triggers intracellular hydrogen peroxide (H2O2) production. Whereas, silencing of beclin1 neither inhibited the hallmarks of autophagy nor the induction of cell death, Atg 7 or Ulk1 knockdown significantly abrogated drug-induced H2O2-mediated autophagy. Furthermore, we provide evidence that activated extracellular regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) are upstream effectors controlling both autophagy and apoptosis in response to elevated intracellular H2O2. Interestingly, inhibition of JNK activity reversed the increase in Atg7 expression in this system, thus indicating that JNK may regulate autophagy by activating Atg7. Of note, the small molecule compound triggered autophagy and apoptosis in primary cells derived from patients with lymphoma, but not in non-transformed cells. Conclusions/Significance: Considering that loss of tumor suppressor beclin 1 is associated with neoplasia, the ability of this small molecule compound to engage both autophagic and apoptotic machineries via ROS production and subsequent activation of ERK and JNK could have potential translational implications.Singapore. Biomedical Research CouncilSingapore. Ministry of Educatio

Viewing versus Experiencing in Adopting Somatosensory Technology for Smart Applications

Emerging somatosensory technology offers unprecedented opportunities for researchers and industrial practitioners to design a touchless smart home system. However, existing touchless smart home systems often fail to attract a satisfying level of acceptance among home owners. The experience users have with the touchless system is key to making somatosensory technology a pervasive computing home application, yet little research has been conducted to assess the influence of direct and indirect experience on user’s behavioral intention to use somatosensory technology. To address this research gap, this paper set up an experimental design to investigate the influence of direct and indirect experience in user technology acceptance. Using an in-house developed touchless system, two experimental studies (i.e., video observation versus product trial) were conducted with sixty-two participants to investigate whether the user experience has an impact on the adoption decision. Our findings indicate that direct experience has an impact on a user’s acceptance of somatosensory technology. We found a significant difference in the relationships between perceived complexity and usage intentions. Perceived complexity was a significant predictor of an individual’s behavioral intention to use the touchless system after video observation, while its relationship to usage intention was insignificant after the user had direct experience with touchless system. Our study reveals an important implication for somatosensory technology marketers, in which product trial (direct experience) engenders more reliable inferences than does exposure to video demonstration (indirect experience). Based on this, companies should devise marketing programme involving direct experience (e.g., product trial and showroom visit) to promote new somatosensory-enabled smart home systems. The results of the study also demonstrate that user experience in research design may influence the results of the Technology Acceptance Model (TAM) studies. Available at: https://aisel.aisnet.org/pajais/vol6/iss3/2